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Semaglutide should be used with a reduced-calorie meal plan and increased physical activity

Physical examination : The doctor might press on your back and sides to check for pain

Here's what the research shows: 8,9 Weight Loss Comparison: Metformin: Average weight loss of 5-6 pounds (2-6% of body weight) Semaglutide: Average weight loss of 8-15 pounds (8-15% of body weight) Tirzepatide: Average weight loss of 15-20% of body weight Key Advantages of Metformin: Oral medication (no injections required) Significantly lower cost 60+ years of proven safety data 1 Can be used in combination with GLP-1 medications 10 Long-term effectiveness demonstrated over 15 years 2 Widely available and covered by most insurance plans Many healthcare providers now prescribe metformin alongside newer medications, leveraging the complementary benefits of both approaches for optimal weight management and metabolic health

For microvascular complications, we estimated the risk reduction at approximately 37% (range: 33%41%)

They can help you find ways to manage both the physical symptoms and the mental health effects

Ozempic (semaglutide) is a GLP-1 receptor agonist licensed in the UK for type 2 diabetes treatment, with common gastrointestinal side effects including nausea and diarrhoea